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Staged pathology in Parkinson's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular and Morphological Pathology.
2014 (English)In: Parkinsonism & Related Disorders, ISSN 1353-8020, E-ISSN 1873-5126, Vol. 20, no Suppl. 1, S57-S61 p.Article in journal (Refereed) Published
Abstract [en]

There has been a tremendous development since a regional progression of pathology in subjects with Lewy bodies (LB) was initially proposed 30 years ago. The entity of dementia with Lewy bodies has been acknowledged, the main protein constituent of LBs--aggregated α-synuclein (αS)--has been identified and a stepwise progression of the pathology has been reported. Implementation of the staging strategies published provides a common ground for handling a case with a suspected α-synucleinopathy. It is always important to state the staging strategy implemented while assessing a case, as the strategy applied might influence both the reported stage of LB pathology and, ultimately, the final diagnosis of the patient.

Place, publisher, year, edition, pages
2014. Vol. 20, no Suppl. 1, S57-S61 p.
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Clinical Laboratory Medicine Basic Medicine
Research subject
URN: urn:nbn:se:uu:diva-224022DOI: 10.1016/S1353-8020(13)70016-6PubMedID: 24262190OAI: oai:DiVA.org:uu-224022DiVA: diva2:714848
Available from: 2014-04-29 Created: 2014-04-29 Last updated: 2015-04-17Bibliographically approved

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