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Effects of Mn-DPDP and manganese chloride on hemodynamics and glucose tolerance in anesthetized rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
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2014 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 55, no 3, 328-334 p.Article in journal (Refereed) Published
Abstract [en]

Background Previous studies have demonstrated that magnetic resonance imaging may be a method of choice to visualize transplanted pancreatic islets. However, contrast agents may interfere with microcirculation and affect graft function. Purpose To evaluate the effects manganese-containing contrast media on regional blood flow and glucose tolerance. Material and Methods Anesthetized rats were injected intravenously with MnCl2 (10 mu M/kg body weight) or Mn-DPDP (Teslascan; 5 mu M/kg body weight). Blood flow measurements were made with a microsphere technique 10min later. In separate animals vascular arteriolar reactivity in isolated, perfused islets was examined. Furthermore, an intraperitoneal glucose tolerance test was performed in separate rats. Results Glucose tolerance was unaffected by both agents. No changes in regional blood flow were seen after administration of Mn-DPDP, except for an increase in arterial liver blood flow. MnCl2 increased all blood flow values except that of the kidney. MnCl2, but not Mn-DPDP, caused a vasoconstriction in isolated rat islet arterioles but only at very high doses. Conclusion Mn-DPDP administration does not affect glucose tolerance or regional blood flow, besides an increase in arterial hepatic blood flow, and may therefore be suitable for visualization of islets.

Place, publisher, year, edition, pages
2014. Vol. 55, no 3, 328-334 p.
Keyword [en]
Pancreatic islets, regional blood flow, radio contrast agents, manganese, glucose tolerance
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-223866DOI: 10.1177/0284185113499327ISI: 000332844000012OAI: oai:DiVA.org:uu-223866DiVA: diva2:716404
Available from: 2014-05-09 Created: 2014-04-28 Last updated: 2017-12-05Bibliographically approved

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Gao, XiangSandberg, MonicaQuach, MyBodin, BirgittaJohansson, LarsJansson, Leif

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