Injectable hyaluronic acid hydrogel for F-19 magnetic resonance imaging
2014 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 110, 95-99 p.Article in journal (Refereed) Published
We report on a19F labeled injectable hyaluronic acid (HA) hydrogel that can be monitored by both 1H and 19F MR imaging. The HA based hydrogel formed via carbazone reaction can be obtained within a minute by simple mixing of HA-carbazate and HA-aldehyde derivatized polymers. 19F contrast agent was linked to with carbazate and thiol dually functionalized HA via orthogonal Michael addition reaction which afforded cross-linkable and 19F labeled HA. The 19F labeling of HA polymer did not affect the mechanical properties of the formed hydrogel. As a result, the shape of a hydrogel sample could be imaged very well by both 1H MRI and high resolution19F MRI. This hydrogel has high potential in clinical applications since it is injectable, biocompatible, and can be tracked in a minimally invasive manner. The present approach can be applied in preparation of injectable 19F labeled hydrogel biomaterials from other natural biomacromolecules.
Place, publisher, year, edition, pages
2014. Vol. 110, 95-99 p.
Polymer Chemistry Materials Chemistry
IdentifiersURN: urn:nbn:se:uu:diva-224259DOI: 10.1016/j.carbpol.2014.03.070ISI: 000338005000013OAI: oai:DiVA.org:uu-224259DiVA: diva2:716449
Injectable hyaluronic acid hydrogel for 19F magnetic resonance imaging2014-05-092014-05-072014-07-25Bibliographically approved