uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Phylogenomic approaches underestimate eukaryotic gene transfer
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab. (Andersson Jan)
2012 (English)In: Mobile Genetic Elements, Vol. 2, no 1, 59-62 p.Article in journal (Refereed) Published
Abstract [en]

Phylogenomic approaches have shown that eukaryotes acquire genes via gene transfer. However, there are two fundamental problems for most of these analyses; only transfers from prokaryotes are analyzed and the screening procedures applied assume that gene transfer is rare for eukaryotes. Directed studies of the impact of gene transfer on diverse eukaryotic lineages produce a much more complex picture. Many gene families are affected by multiple transfer events from prokaryotes to eukaryotes, and transfers between eukaryotic lineages are routinely detected. This suggests that the assumptions applied in traditional phylogenomic approaches are too naïve and result in many false negatives. This issue was recently addressed by identifying and analyzing the evolutionary history of 49 patchily distributed proteins shared between Dictyostelium and bacteria. The vast majority of these gene families showed strong indications of gene transfers, both between and within the three domains of life. However, only one of these was previously reported as a gene transfer candidate using a traditional phylogenomic approach. This clearly illustrates that more realistic assumptions are urgently needed in genome-wide studies of eukaryotic gene transfer.

Place, publisher, year, edition, pages
2012. Vol. 2, no 1, 59-62 p.
National Category
Evolutionary Biology
URN: urn:nbn:se:uu:diva-224548DOI: 10.4161/mge.19668OAI: oai:DiVA.org:uu-224548DiVA: diva2:717109
Available from: 2014-05-14 Created: 2014-05-14 Last updated: 2014-05-14Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Andersson, Jan O
By organisation
Molecular EvolutionScience for Life Laboratory, SciLifeLab
Evolutionary Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 856 hits
ReferencesLink to record
Permanent link

Direct link