uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Effect of hydrophobic modifications in antimicrobial peptides
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2014 (English)In: Advances in Colloid and Interface Science, ISSN 0001-8686, E-ISSN 1873-3727, Vol. 205, 265-274 p.Article in journal (Refereed) Published
Abstract [en]

With increasing resistance development against conventional antibiotics, there is an urgent need to identify novel approaches for infection treatment. Antimicrobial peptides may offer opportunities in this context, hence there has been considerable interest in identification and optimization of such peptides during the last decade in particular, with the long-term aim of developing these to potent and safe therapeutics. In the present overview, focus is placed on hydrophobic modifications of antimicrobial peptides, and how these may provide opportunities to combat also more demanding pathogens, including multi-resistant strains, yet not provoking unacceptable toxic responses. In doing so, physicochemical factors affecting peptide interactions with bacterial and eukaryotic cell membranes are discussed. Throughout, an attempt is made to illustrate how physicochemical studies on model lipid membranes can be correlated to result from bacterial and cell assays, and knowledge from this translated into therapeutic considerations. (C) 2013 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2014. Vol. 205, 265-274 p.
Keyword [en]
AMP, Antimicrobial peptide, Bacteria, Liposome, Membrane
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-224472DOI: 10.1016/j.cis.2013.06.009ISI: 000333780600020OAI: oai:DiVA.org:uu-224472DiVA: diva2:717412
Available from: 2014-05-15 Created: 2014-05-13 Last updated: 2014-05-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Malmsten, Martin
By organisation
Department of Pharmacy
In the same journal
Advances in Colloid and Interface Science
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 164 hits
ReferencesLink to record
Permanent link

Direct link