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Estimating the cure proportion of malignant melanoma, an alternative approach to assess long term survival: A population-based study
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2014 (English)In: Cancer Epidemiology, ISSN 1877-7821, Vol. 38, no 1, 93-99 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: A large proportion of patients with cutaneous malignant melanoma (CMM) do not experience excess mortality due to their disease. This group of patients is referred to as the cure proportion. Few studies have examined the possibility of cure for CMM. The aim of this study was to estimate the cure proportion of patients with CMM in a Swedish population. Methods: We undertook a population-based study of 5850 CMM patients in two Swedish health care regions during 1996-2005. We used flexible parametric cure models to estimate cure proportions and median survival times (MSTs) of uncured by stage, sex, age and anatomical site. Results: Disease stage at diagnosis was the most important factor for the probability of cure, with a cure proportion of approximately 1.0 for stage IA. While the probability of cure decreased with older age, the influence of age was smaller on the MST of uncured. Differences in prognosis between males and females were mainly attributed to differences in cure as opposed to differences in MST of uncured. Conclusions: This population-based study showed approximately 100% cure among stage IA disease. Almost 50% of patients had stage IA disease and the high cure proportion for this large patient group is reassuring.

Place, publisher, year, edition, pages
2014. Vol. 38, no 1, 93-99 p.
Keyword [en]
Malignant melanoma, Survival, Cure, Population-based, Flexible parametric model, Relative survival
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-224590DOI: 10.1016/j.canep.2013.12.006ISI: 000334029800015OAI: oai:DiVA.org:uu-224590DiVA: diva2:717529
Available from: 2014-05-15 Created: 2014-05-14 Last updated: 2014-05-15Bibliographically approved

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Dickman, Paul W.
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UCR-Uppsala Clinical Research Center
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