uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The role of SATB2 as a diagnostic marker for tumors of colorectal origin: Results of a pathology-based clinical prospective study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular and Morphological Pathology.
Show others and affiliations
2014 (English)In: American Journal of Clinical Pathology, ISSN 0002-9173, E-ISSN 1943-7722, Vol. 141, no 5, 630-638 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Immunohistochemistry is an important extension to clinical information and morphology, and prevails as an invaluable tool for establishing a correct cancer diagnosis in clinical diagnostic pathology. The applicability of immunohistochemistry is limited by the availability of validated cell- and cancer-type specific antibodies, rendering an unmet need to discover, test, and validate novel markers. The SATB2 protein is selectively expressed in glandular cells from the lower gastrointestinal tract and expression is retained in a large majority of primary and metastatic colorectal cancers.

METHODS: We analyzed the expression of SATB2 in all clinical cases (n = 840), in which immunohistochemistry for detection of CK20 was deemed necessary for a final diagnosis.

RESULTS: SATB2 showed a high sensitivity (93%) and specificity (77%) to determine a cancer of colorectal origin and in combination with CK7 and CK20, the specificity increased to 100%.

CONCLUSIONS: We conclude that SATB2 provides a new and advantageous supplement for clinical differential diagnostics.

Place, publisher, year, edition, pages
2014. Vol. 141, no 5, 630-638 p.
National Category
Clinical Laboratory Medicine Basic Medicine
Research subject
URN: urn:nbn:se:uu:diva-224759DOI: 10.1309/AJCPWW2URZ9JKQJUISI: 000335200400004PubMedID: 24713733OAI: oai:DiVA.org:uu-224759DiVA: diva2:718115
Available from: 2014-05-19 Created: 2014-05-19 Last updated: 2016-02-26

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Pontén, Fredrik
By organisation
Molecular and Morphological Pathology
In the same journal
American Journal of Clinical Pathology
Clinical Laboratory MedicineBasic Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 162 hits
ReferencesLink to record
Permanent link

Direct link