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The humerus of Eusthenopteron: a puzzling organization presaging the establishment of tetrapod limb bone marrow
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
2014 (English)In: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 281, no 1782, 20140299- p.Article in journal (Refereed) Published
Abstract [en]

Because of its close relationship to tetrapods, Eusthenopteron is an important taxon for understanding the establishment of the tetrapod body plan. Notably, it is one of the earliest sarcopterygians in which the humerus of the pectoral fin skeleton is preserved. The microanatomical and histological organization of this humerus provides important data for understanding the evolutionary steps that built up the distinctive architecture of tetrapod limb bones. Previous histological studies showed that Eusthenopteron's long-bone organization was established through typical tetrapod ossification modalities. Based on a threedimensional reconstruction of the inner microstructure of Eusthenopteron's humerus, obtained from propagation phase-contrast X-ray synchrotron microtomography, we are now able to show that, despite ossification mechanisms and growth patterns similar to those of tetrapods, it also retains plesiomorphic characters such as a large medullary cavity, partly resulting from the perichondral ossification around a large cartilaginous bud as in actinopterygians. It also exhibits a distinctive tubular organization of bone-marrow processes. The connection between these processes and epiphyseal structures highlights their close functional relationship, suggesting that either bone marrow played a crucial role in the long-bone elongation processes or that trabecular bone resulting from the erosion of hypertrophied cartilage created a microenvironment for haematopoietic stem cell niches.

Place, publisher, year, edition, pages
2014. Vol. 281, no 1782, 20140299- p.
Keyword [en]
early tetrapod limb bone, growth plate, evolution, synchrotron virtual bone histology, life history
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-224984DOI: 10.1098/rspb.2014.0299ISI: 000334410100031OAI: oai:DiVA.org:uu-224984DiVA: diva2:719824
Available from: 2014-05-27 Created: 2014-05-26 Last updated: 2017-12-05Bibliographically approved

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Sanchez, SophieAhlberg, Per E.

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