uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Genetic variation in the CYP2B6 Gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-2071-5866
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Show others and affiliations
2014 (English)In: Environmental health, ISSN 1476-069X, E-ISSN 1476-069X, Vol. 13, 34- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Since human CYP2B6 has been identified as the major CYP enzyme involved in the metabolism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and that human 2B6 is a highly polymorphic CYP, with known functional variants, we evaluated if circulating concentrations of a major brominated flame retardant, BDE-47, were related to genetic variation in the CYP2B6 gene in a population sample.

METHODS:

In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (men and women all aged 70), 25 single nucleotide polymorphisms (SNPs) in the CYP2B6 gene were genotyped. Circulating concentrations of BDE-47 were analyzed by high-resolution gas chromatography coupled to high-resolution mass spectrometry (HRGC/ HRMS).

RESULTS:

Several SNPs in the CYP2B6 gene were associated with circulating concentrations of BDE-47 (P = 10-4 to 10-9). The investigated SNPs came primarily from two haplotypes, although the correlation between the haplotypes was rather high. Conditional analyses adjusting for the SNP with the strongest association with the exposure (rs2014141) did not provide evidence for independent signals.

CONCLUSION:

Circulating concentrations of BDE-47 were related to genetic variation in the CYP2B6 gene in an elderly population.

Place, publisher, year, edition, pages
2014. Vol. 13, 34- p.
National Category
Other Clinical Medicine
Identifiers
URN: urn:nbn:se:uu:diva-225448DOI: 10.1186/1476-069X-13-34ISI: 000336098900001PubMedID: 24885815OAI: oai:DiVA.org:uu-225448DiVA: diva2:721201
Available from: 2014-06-03 Created: 2014-06-03 Last updated: 2017-12-05Bibliographically approved

Open Access in DiVA

fulltext(701 kB)125 downloads
File information
File name FULLTEXT01.pdfFile size 701 kBChecksum SHA-512
930e018a5f17da8297c0949c00d178fd4b15646279c02945374f8556fc6afa148daead7b3065a9ae551296b6b30aa3dde6191cf81e383893c7e64a17f10ca481
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Penell, JohannaLind, LarsFall, ToveSyvänen, Ann-ChristineAxelsson, TomasLundmark, PerIngelsson, ErikLind, P Monica

Search in DiVA

By author/editor
Penell, JohannaLind, LarsFall, ToveSyvänen, Ann-ChristineAxelsson, TomasLundmark, PerIngelsson, ErikLind, P Monica
By organisation
Occupational and Environmental MedicineCardiovascular epidemiologyMolecular epidemiologyScience for Life Laboratory, SciLifeLabMolecular Medicine
In the same journal
Environmental health
Other Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 125 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 433 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf