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Syntheses of new tuberculosis inhibitors promoted by microwave irradiation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
2014 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 119, no 2, 181-191 p.Article, review/survey (Refereed) Published
Abstract [en]

Tuberculosis (TB) represents a major public health problem. The growing number of (extensively) multi-drug resistance cases indicates that there is an urgent need for discovery of new anti-TB entities, addressed towards new and specific targets, and continuous development of fast and efficient synthetic strategies to access them easily. Microwave-assisted chemistry is well suited for small-scale laboratory synthetic work, allowing full control of reaction conditions, such as temperature, pressure, and time. Microwave-assisted high-speed organic synthesis is especially useful in the lead optimization phase of drug discovery. To illustrate the advantages of modern microwave heating technology, we herein describe applications and approaches that have been useful for the synthesis of new drug-like anti-TB compounds.

Place, publisher, year, edition, pages
2014. Vol. 119, no 2, 181-191 p.
National Category
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-225732DOI: 10.3109/03009734.2014.899655ISI: 000336526100018PubMedID: 24666224OAI: oai:DiVA.org:uu-225732DiVA: diva2:722161
Available from: 2014-06-05 Created: 2014-06-05 Last updated: 2017-12-05Bibliographically approved

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De Rosa, MariaGising, JohanOdell, Luke RLarhed, Mats

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