1090 nm infrared radiation at close to threshold dose induces cataract with a time delay
2015 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 93, no 2, e118-e122 p.Article in journal (Refereed) Published
To investigate if infrared radiation induced cataract is instant or is associatedwith a time delay between the exposure and the onset of lens light scattering after anexposure to just above threshold dose.
Six-weeks-old albino Sprague-Dawley female rats were unilaterally exposedto 197 W/cm2 infrared radiation at 1090 nm within the dilated pupil. In the firstexperiment, the animals were exposed with four exposure times of 5, 8, 13 and 20 s,respectively. At 24 h after exposure, the light scattering in both exposed andcontralateral not exposed lenses was measured. Based on the first experiment, fourpost exposure time groups were exposed unilaterally to 1090 nm infrared radiation of197 W/cm2 for 8 s. At 6, 18, 55 and 168 h after exposure, the light scattering in bothlenses was measured.
A 197 W/cm2 infrared radiation induced light scattering in the lens withexposures of at least 8 s. Further, after exposure to infrared radiation of 197 W/cm2for 8 s, the light scattering increase in the lens was delayed approximately 16 h afterthe exposure.
There is a time delay between the exposure and the onset of cataract afterexposure to close to threshold dose implicating that either near infrared radiationcataract is photochemical or there is a time delay in the biological expression ofthermally induced damage.
Place, publisher, year, edition, pages
2015. Vol. 93, no 2, e118-e122 p.
infrared radiation, forward light scattering, lens, photochemical, thermal
Basic Medicine Ophthalmology
Research subject Ophtalmology
IdentifiersURN: urn:nbn:se:uu:diva-226530DOI: 10.1111/aos.12508ISI: 000349900200005OAI: oai:DiVA.org:uu-226530DiVA: diva2:726286