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Idenitification of the active site of poly(A)-specific ribonuclease by site-directed mutagensis and Fe2+-mediated cleavage.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology. MOLECULAR CELLBIOLOGY.
2002 (English)In: . J. Biol. Chem., Vol. 277, 5982-5987 p.Article in journal (Refereed) Published
Abstract [en]

Poly(A)-specific ribonuclease (PARN) is the only so far characterized mammalian exoribonuclease with high specificity for degrading the mRNA poly(A) tail. PARN belongs to the RNase D family of nucleases, a family characterized by the presence of four

Place, publisher, year, edition, pages
2002. Vol. 277, 5982-5987 p.
URN: urn:nbn:se:uu:diva-44967OAI: oai:DiVA.org:uu-44967DiVA: diva2:72874
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-13

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