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Morphometric analysis of vessel density in breast carcinomain relation to their Nottingham’s score
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
2013 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Globally, breast cancer is the most abundant cancer form in women, in Sweden about 20 women are diagnosed with breast cancer every day .Interactions between genetic and external factors are the contributing factors while metastasis formation is the leading cause of death. Cancer is in need of vessels,to get the nutrients and oxygen it needs in order to survive. Therefore,the aim of the study is to analyze and compare the groups of high and low differential cancer vessels of the respective form, and to see if any type contained more vessels than the other. The study is based on 20 invasive ductal breast cancer samples, ten of them were high differentiated and the other ten were low differentiated. To assess the number of vessels, immunhistochemical staining with CD31 antibody was performedCD31 is an adhesion molecule present on endothelial cells. The group of low differentiated gradebreast cancer tissue had significantly more vessels compared with the high differentiated breast cancer tissues. To prove these test results, more cancers must be analyzed.

Place, publisher, year, edition, pages
2013. , 14 p.
Keyword [en]
Angiogenesis, CD31, Differentiation, Invasive breast cancer, Rating
National Category
Biomedical Laboratory Science/Technology
URN: urn:nbn:se:uu:diva-227239OAI: oai:DiVA.org:uu-227239DiVA: diva2:728745
Educational program
Biomedical Laboratory Science Programme
Available from: 2014-08-25 Created: 2014-06-24 Last updated: 2014-08-25Bibliographically approved

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