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The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
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2014 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 446, no 3, 681-686 p.Article in journal (Refereed) Published
Abstract [en]

Dendrogenin A (DDA) and dendrogenin B (DDB) are new aminoalkyl oxysterols which display re-differentiation of tumor cells of neuronal origin at nanomolar concentrations. We analyzed the influence of dendrogenins on adult mice neural stem cell proliferation, sphere formation and differentiation. DDA and DDB were found to have potent proliferative effects in neural stem cells. Additionally, they induce neuronal outgrowth from neurospheres during in vitro cultivation. Taken together, our results demonstrate a novel role for dendrogenins A and B in neural stem cell proliferation and differentiation which further increases their likely importance to compensate for neuronal cell loss in the brain. (C) 2014 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
2014. Vol. 446, no 3, 681-686 p.
Keyword [en]
Neural stem cells, Neurosteroids, Oxysterols, Dendrogenin
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-227204DOI: 10.1016/j.bbrc.2013.12.134ISI: 000335543600008OAI: oai:DiVA.org:uu-227204DiVA: diva2:729752
Available from: 2014-06-26 Created: 2014-06-24 Last updated: 2017-12-05Bibliographically approved

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Erlandsson, AnnaEl-Seedi, Hesham R.

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Department of Public Health and Caring SciencesDivision of Pharmacognosy
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