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Increased plasma glucose levels after change of recommendation from NaF to citrate blood collection tubes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
2014 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 47, no 7-8, 625-628 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To evaluate changes in plasma glucose measurements in an unselected patient population after a change of recommendation from NaF to citrate blood collection vacuum tubes. Design and methods: Glucose (n = 460 751) and HbA1c (n = 55 190) determinations during a period of approximately three years before and after the tube change were extracted from a laboratory information system. Results: Median values for plasma glucose determinations increased from 6.03 before to 6.28 mmol/L after the tube change. The proportion of glucose determinations above the WHO limit for impaired fasting glucose (6.1 mmol/L) and the medical decision limit for diabetes (7.0 mmol/L) increased from 48.1 to 55.4% after the change. Conclusions: The change from NaF to citrate tubes caused higher glucose values, and consequently more glucose determinations above the decision limit for diabetes.

Place, publisher, year, edition, pages
2014. Vol. 47, no 7-8, 625-628 p.
Keyword [en]
Blood collection tube, Glucose, Plasma, Preanalytical process, Sample stability
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:uu:diva-227265DOI: 10.1016/j.clinbiochem.2014.02.022ISI: 000335905200022OAI: oai:DiVA.org:uu-227265DiVA: diva2:731727
Available from: 2014-07-02 Created: 2014-06-24 Last updated: 2017-12-05Bibliographically approved

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Ridefelt, PeterÅkerfeldt, TorbjörnHelmersson-Karlqvist, Johanna

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