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A Systematic Approach to Document Cyclotide Distribution in Plant Species from Genomic, Transcriptomic, and Peptidomic Analysis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
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2013 (English)In: Biopolymers, ISSN 0006-3525, E-ISSN 1097-0282, Vol. 100, no 5, 433-437 p.Article in journal (Refereed) Published
Abstract [en]

Cyclotides are a large family of plant peptides characterized by their cyclic cystine knot composed of a circular backbone and three disulfide bonds that impart exceptional stability. They, and several acyclic variants, have been isolated from plants within the Rubiaceae, Violaceae, Cucurbitaceae, Fabaceae, Solanaceae, and Poaceae families. A variety of chemical and genetic approaches have been applied for the discovery and characterization of cyclotides. As investigations of cyclotide expression, distribution, and phylogeny rapidly increase, the authors have proposed the inclusion of information pertaining to plant species that have been analyzed but do not appear to express cyclotides into the CyBase database. CyBase is dedicated to providing web tools and information about cyclic peptides and proteins to the scientific community. Including detailed information about sampling and analysis parameters of plant species that have been investigated but not published elsewhere should assist in the process of selecting species for establishing new cyclotide discovery projects, as well as for detailed reanalysis using alternative technical approaches. In summary, the collection and deposition of all plant species that have been examined (whether cyclotides have been found or not) would help to impart a deeper understanding of cyclotide discovery, evolution, and physiological function.

Place, publisher, year, edition, pages
2013. Vol. 100, no 5, 433-437 p.
Keyword [en]
CyBase, cyclotides, discovery, screening, deposition
National Category
Biochemistry and Molecular Biology Biophysics
URN: urn:nbn:se:uu:diva-227968DOI: 10.1002/bip.22258ISI: 000336527900002OAI: oai:DiVA.org:uu-227968DiVA: diva2:731897
Available from: 2014-07-02 Created: 2014-07-02 Last updated: 2014-07-02Bibliographically approved

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Göransson, Ulf
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