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In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
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2014 (English)In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 57, 99-151 p.Article in journal (Refereed) Published
Abstract [en]

This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the existing in vivo models and demonstrate their usefulness in drug formulation and product performance testing. (c) 2014 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2014. Vol. 57, 99-151 p.
Keyword [en]
In vivo model selection, Biopharmaceutic characterization, Bioavailability, Drug product development
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-227996DOI: 10.1016/j.ejps.2014.02.010ISI: 000336471400013OAI: oai:DiVA.org:uu-227996DiVA: diva2:732304
Available from: 2014-07-03 Created: 2014-07-02 Last updated: 2014-07-03Bibliographically approved

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Sjögren, ErikLennernäs, Hans
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