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An update on alkylresorcinols - Occurrence, bioavailability, bioactivity and utility as biomarkers
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
2014 (English)In: Journal of Functional Foods, ISSN 1756-4646, Vol. 7, 77-89 p.Article, review/survey (Refereed) Published
Abstract [en]

Alkylresorcinols (AR) with alkyl chains in the range of C15 to C25 are phenolic lipids particularly abundant in the outer parts of wheat and rye kernels and in food products containing these parts. The content in whole grain and bran products is high (200-4000 mu g/g), whereas only trace-levels are detected in refined products. Alkylresorcinols are absorbed in humans in proportion to intake and have therefore been suggested and evaluated as biomarkers for whole grain wheat and rye intake. In humans, plasma AR concentrations reach micromolar concentrations immediately after whole grain wheat and rye product consumption and nano-molar levels at fasting conditions. Results from different model studies have indicated that AR may have some bioactivities including enzyme inhibition, suppression of adipocyte lipolysis and inhibition of colon cancer tumor growth but it is currently unknown whether AR bioactive in vivo or not. This chapter details the recent research findings on alkylresorcinols with emphasis on their occurrence, bioavailability, bioactivity and utility as biomarkers.

Place, publisher, year, edition, pages
2014. Vol. 7, 77-89 p.
Keyword [en]
Alkylresoricinols, Biomarkers, Bioavailability, Bioactivity
National Category
Food Science
URN: urn:nbn:se:uu:diva-228242DOI: 10.1016/j.jff.2013.09.004ISI: 000335203500007OAI: oai:DiVA.org:uu-228242DiVA: diva2:733285
Available from: 2014-07-08 Created: 2014-07-08 Last updated: 2014-07-08Bibliographically approved

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Marklund, Matti
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