uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Does Mortality Risk of Cigarette Smoking Depend on Serum Concentrations of Persistent Organic Pollutants?: Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
Show others and affiliations
2014 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 9, no 5, e95937- p.Article in journal (Refereed) Published
Abstract [en]

Cigarette smoking is an important cause of preventable death globally, but associations between smoking and mortality vary substantially across country and calendar time. Although methodological biases have been discussed, it is biologically plausible that persistent organic pollutants (POPs) like polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides can affect this association. This study was performed to evaluate if associations of cigarette smoking with mortality were modified by serum concentrations of PCBs and OC pesticides. We evaluated cigarette smoking in 111 total deaths among 986 men and women aged 70 years in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) with mean follow-up for 7.7 years. The association between cigarette smoking and total mortality depended on serum concentration of PCBs and OC pesticides (P value for interaction = 0.02). Among participants in the highest tertile of the serum POPs summary score, former and current smokers had 3.7 (95% CI, 1.5-9.3) and 6.4 (95% CI, 2.3-17.7) times higher mortality hazard, respectively, than never smokers. In contrast, the association between cigarette smoking and total mortality among participants in the lowest tertile of the serum POPs summary score was much weaker and statistically nonsignificant. The strong smoking-mortality association observed among elderly people with high POPs was mainly driven by low risk of mortality among never smokers with high POPs. As smoking is increasing in many low-income and middle-income countries and POPs contamination is a continuing problem in these areas, the interactions between these two important health-related issues should be considered in future research.

Place, publisher, year, edition, pages
2014. Vol. 9, no 5, e95937- p.
National Category
Cardiac and Cardiovascular Systems Environmental Health and Occupational Health
URN: urn:nbn:se:uu:diva-228480DOI: 10.1371/journal.pone.0095937ISI: 000336857400019OAI: oai:DiVA.org:uu-228480DiVA: diva2:734223
Available from: 2014-07-15 Created: 2014-07-15 Last updated: 2014-07-15Bibliographically approved

Open Access in DiVA

fulltext(244 kB)42 downloads
File information
File name FULLTEXT01.pdfFile size 244 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Lind, LarsLind, Monica P.
By organisation
Cardiovascular epidemiologyOccupational and Environmental Medicine
In the same journal
Cardiac and Cardiovascular SystemsEnvironmental Health and Occupational Health

Search outside of DiVA

GoogleGoogle Scholar
Total: 42 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 237 hits
ReferencesLink to record
Permanent link

Direct link