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Using Nanofluidic Channels to Probe the Dynamics of Rad51-DNA Filaments
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational and Systems Biology.
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2014 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 106, no 2, 692A-693A p.Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Rad51 is a key protein involved in the strand exchange reaction, a reaction where genetic material is transferred between two homologous DNA strands. Strand exchange is initiated by Rad51 forming a helical filament around single-stranded DNA (ssDNA), and the strand exchange is thereafter executed with a homologous double-stranded DNA (dsDNA). The structure of Rad51-DNA filaments, and also the activity of the strand exchange reaction, is dependent on the presence of ATP and dications, where Ca2+ has been shown to promote a higher degree of strand exchange than Mg2+.

Place, publisher, year, edition, pages
2014. Vol. 106, no 2, 692A-693A p.
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Biophysics
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URN: urn:nbn:se:uu:diva-228607DOI: 10.1016/j.bpj.2013.11.3830ISI: 000337000403851OAI: oai:DiVA.org:uu-228607DiVA: diva2:734554
Conference
58th Annual Meeting of the Biophysical-Society, FEB 15-19, 2014, San Francisco, CA
Available from: 2014-07-18 Created: 2014-07-17 Last updated: 2017-12-05Bibliographically approved

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Persson, Fredrik

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