Origin of the Architecture of Biological Macromolecules - A Mean-Field Perspective
2014 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 106, no 2, 256A-256A p.Article in journal, Meeting abstract (Other academic) Published
The structures of the key classes of biological macromolecules: proteins, nucleic acids and polysaccharides can be dissected into very regular motifs, which are alpha-, beta, and double helices and sheets. In this communication we demonstrate that these regular patterns arise as a result of dipole-dipole interactions of the polar groups (peptide, nucleic-acid-base or sugar-ring groups) and the coupling of these interactions with backbone-local interactions, described at the mean-field level; the averaging is carried out by rotating the dipole of a polar unit about its virtual-bond axis.
Place, publisher, year, edition, pages
2014. Vol. 106, no 2, 256A-256A p.
IdentifiersURN: urn:nbn:se:uu:diva-228599DOI: 10.1016/j.bpj.2013.11.1506ISI: 000337000401415OAI: oai:DiVA.org:uu-228599DiVA: diva2:734569
58th Annual Meeting of the Biophysical-Society, FEB 15-19, 2014, San Francisco, CA