Life style intervention in moderately overweight individuals is associated with decreased levels of cathepsins L and S in plasma
2014 (English)In: Annals of Clinical and Laboratory Science, ISSN 0091-7370, Vol. 44, no 3, 283-285 p.Article in journal (Refereed) Published
Background Adipose tissue cells produce cathepsins L and S, which have proatherogenic effects. Obesity is strongly linked to atherogenesis, cardiovascular morbidity, and mortality.
Objective The aim of the present study was to see if life style interventions/weight reduction could decrease cathepsin L and S levels in blood plasma.
Method Study subjects (n=31) were recruited to a life style intervention program aiming at increased physical activity, more healthy eating habits, and weight reduction for most of the participants. Blood samples were collected at inclusion and after 4 and 8 weeks.
Results Cathepsin L was significantly reduced at 4 weeks (p<0.0001) and 8 weeks (p=0.0004). A similar reduction was also seen for cathepsin S at 4 weeks (p=0.03) and 8 weeks (p=0.008). No significant change in fractalkine values was observed at 4 weeks (p=0.58), but a significant increase was apparent at 8 weeks (p=0.0002).
Conclusion The intervention program resulted in significant reductions of cathepsin L and S levels in plasma after 4 and 8 weeks of intervention.
Place, publisher, year, edition, pages
2014. Vol. 44, no 3, 283-285 p.
Nutrition and Dietetics
IdentifiersURN: urn:nbn:se:uu:diva-228732ISI: 000344755600007PubMedID: 25117098OAI: oai:DiVA.org:uu-228732DiVA: diva2:734735