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An audit of antimicrobial treatment of lower respiratory and urinary tract infections in a hospital setting
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2014 (English)In: European Journal of Hospital Pharmacy-Science and Practice, ISSN 2047-9956, Vol. 21, no 3, 139-144 p.Article in journal (Refereed) Published
Abstract [en]

Objectives To audit the quality of treatment of lower respiratory tract infections (LRTIs) and urinary tract infections (UTIs) and to identify targets for antibiotic stewardship. Methods The audit involved collecting data on admitted patients, who were diagnosed with LRTIs or UTIs and subsequently received antibiotic treatment (January 2009-April 2009). Key findings The percentage adherence rate for hospital antibiotic policy was 68.6% (24/35). Documentation of the CURB-65 score was found in 80% (16/20) of the patients' clinical notes, for which 46.2% (6/13) of patients were treated according to their CURB-65 score. The percentages of delayed and missed doses for all antibiotics were 21.7% (254/1171) and 8.6% (101/1171), respectively. The percentage of patients switched from intravenous to oral antibiotics in accordance with the policy was 58.5% (31/53). The mean length of stay for patients switched in line with the guidelines was 6.9days (range: 2-18 days) compared with 13.2days (range: 4-28 days) for patients treated with intravenous antibiotics >24h after the intravenous to oral switch criteria were fulfilled; this equates to on average an extra 6.3days of hospitalisation (p=0.01). Conclusions The study identified a number of targets for quality improvement including adherence to antibiotic policy, documentation of the CURB-65 score in patients' notes and treating patients accordingly, addressing the issue of missed and delayed doses, and maintaining adherence to the hospital intravenous-to-oral antibiotic switch policy. The findings suggest that the quality of antibiotic prescribing could be improved by measuring and addressing such performance indicators.

Place, publisher, year, edition, pages
2014. Vol. 21, no 3, 139-144 p.
Keyword [en]
Clinical Pharmacy, Infectious Diseases, Microbiology
National Category
Microbiology in the medical area Infectious Medicine
URN: urn:nbn:se:uu:diva-228714DOI: 10.1136/ejhpharm-2013-000394ISI: 000337695600003OAI: oai:DiVA.org:uu-228714DiVA: diva2:734840
Available from: 2014-07-21 Created: 2014-07-21 Last updated: 2014-07-21Bibliographically approved

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Microbiology in the medical areaInfectious Medicine

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