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A personal voyage through the proteoglycan field
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2014 (English)In: Matrix Biology, ISSN 0945-053X, E-ISSN 1569-1802, Vol. 35, 3-7 p.Article in journal (Refereed) Published
Abstract [en]

The concept of "proteoglycans" as discrete molecules surfaced some 40 years ago, out of previously muddled notions of the extracellular matrix. Core proteins were gradually recognized as molecular entities, distinct with regard to location, substitution with glycosaminoglycan (GAG) chains and biological function. This development is surveyed, with brief outline of methodological approaches, biosynthesis, and functional aspects. Special emphasis is given to the impact of genomics on the field. Some outstanding unresolved issues are emphasized, including regulation of GAG biosynthesis and the specificity of GAG-protein interactions.

Place, publisher, year, edition, pages
2014. Vol. 35, 3-7 p.
Keyword [en]
Heparan sulfate, Chondroitin sulfate, GAGosome, Core proteins, Glycosaminoglycan chain, Glycosaminoglycan biosynthesis, Glycosaminoglycan-protein interactions
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:uu:diva-228818DOI: 10.1016/j.matbio.2014.01.001ISI: 000337556500002PubMedID: 24463261OAI: oai:DiVA.org:uu-228818DiVA: diva2:735063
Available from: 2014-07-22 Created: 2014-07-22 Last updated: 2014-07-22Bibliographically approved

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