uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Implications of heparan sulfate and heparanase in neuroinflammation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2014 (English)In: Matrix Biology, ISSN 0945-053X, E-ISSN 1569-1802, Vol. 35, 174-181 p.Article, review/survey (Refereed) Published
Abstract [en]

Heparan sulfate proteoglycans (HSPGs), expressed on the cell surface and in the extracellular matrix of most animal tissues, have essential functions in development and homeostasis, and have been implicated in several pathological conditions. The functions of HSPGs are mainly mediated through interactions of the heparan sulfate (HS) polysaccharide side chains with different protein ligands. The molecular structure of HS is highly diverse, expressed in a cell-type specific manner. The flexible yet controlled structure of HS is primarily generated through a strictly regulated biosynthesis process and is further modified post-synthetically, such as desulfation by endosulfatases and fragmentation by heparanase. Heparanase is an endo-glucuronidase expressed in all tissues. The enzyme has been found up-regulated in a number of pathological conditions, implying a role in diseases mainly through degradation of HS. Emerging evidence demonstrates important roles of HS and heparanase in inflammatory reactions, particularly in the regulation of leukocyte activation and extravasation. Neuroinflammation is a common feature of various central nervous system disorders, thus it is a great interest to understand the implications of HS and heparanase in neuroinflammation.

Place, publisher, year, edition, pages
2014. Vol. 35, 174-181 p.
Keyword [en]
Heparan sulfate proteoglycan, Heparanase, Neuroinflammation, Brain, Alzheimer's disease
National Category
Microbiology in the medical area Neurosciences
URN: urn:nbn:se:uu:diva-228913DOI: 10.1016/j.matbio.2013.12.009ISI: 000337556500022OAI: oai:DiVA.org:uu-228913DiVA: diva2:735088
Available from: 2014-07-22 Created: 2014-07-22 Last updated: 2014-07-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full texthttp://www.sciencedirect.com/science/article/pii/S0945053X13001777#

Search in DiVA

By author/editor
Zhang, XiaoLi, Jin-Ping
By organisation
PharmacologyDepartment of Medical Biochemistry and Microbiology
In the same journal
Matrix Biology
Microbiology in the medical areaNeurosciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 252 hits
ReferencesLink to record
Permanent link

Direct link