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The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
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2014 (English)In: Urologic Oncology, ISSN 1078-1439, E-ISSN 1873-2496, Vol. 32, no 5, 613-618 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To analyze microRNA profile in Ta and T1 urinary bladder cancers in combination and separately and to relate this to the risk of later developing higher-stage disease. Materials and methods: Formalin-fixed, paraffin-embedded samples of 44 Ta and 42 T1 bladder cancers representing cases with and without stage progression during follow-up were collected and microRNA expression levels were measured by microarray analysis. Results: In a comparison between the progressors and controls, in the Ta/T1 group, miR-10a-5p and miR-31-5p were differentially expressed. miR-10a-5p was also correlated to time to progression (P = 0.00012). In the subgroup analysis, 3 microRNAs, miR-10a-5p, miR-31-5p, and miR-130a-3p, were differentially expressed among Ta tumors and had a fold change of more than 1.5 (P < 0.038). The comparison concerning microRNA expression between the progressors and controls in category T1 cancers revealed no significant differences. Conclusions: Profiling revealed that certain microRNAs predicted the risk of developing higher-stage disease among patients with Ta cancers. Lower miR-10a-5p expression in Ta progressing tumors indicates that this microRNA could be important for later malignant potential among this group of patients. 

Place, publisher, year, edition, pages
2014. Vol. 32, no 5, 613-618 p.
Keyword [en]
Bladder neoplasms, MicroRNA, Prognosis, Case-control study
National Category
Surgery Urology and Nephrology
URN: urn:nbn:se:uu:diva-228985DOI: 10.1016/j.urolonc.2013.11.001ISI: 000338090800015OAI: oai:DiVA.org:uu-228985DiVA: diva2:735283
Available from: 2014-07-24 Created: 2014-07-24 Last updated: 2014-07-24Bibliographically approved

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Segersten, UlrikaMalmström, Per-Uno
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