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Bacteria-material surface interactions: methodological development for the assessment of implant surface induced antibacterial effects.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material, Nanotechnology and Functional Materials)
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2015 (English)In: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981, Vol. 103, no 1, 179-187 p.Article in journal (Refereed) Published
Abstract [en]

The choice of material for implanted prostheses is of great importance concerning bacterial colonization and biofilm formation. Consequently, methods to investigate bacterial behavior are needed in order to develop new infection resistant surfaces. In this study, different methodological setups were used to evaluate the antimicrobial effect of photocatalytic titanium oxide and silver surfaces. Biofilm formation and eradication under static and dynamic culture conditions were studied with the use of the following analytical techniques: viable colony-forming unit (CFU) counting, imprinting, fluorescence, and bioluminescence. The present study demonstrates that different methods are needed in order to evaluate the prophylactic and treatment effects on planktonic and biofilm bacteria and to assess the antimicrobial effect of different surface treatments/coatings. Choosing the right antibacterial testing model for the specific application is also of great importance. Both in situ approaches and indirect methods provide valuable complementary information. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2014.

Place, publisher, year, edition, pages
2015. Vol. 103, no 1, 179-187 p.
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials; Engineering Science with specialization in Materials Science
URN: urn:nbn:se:uu:diva-229109DOI: 10.1002/jbm.b.33179ISI: 000346191600021PubMedID: 24816674OAI: oai:DiVA.org:uu-229109DiVA: diva2:735712
Available from: 2014-07-30 Created: 2014-07-30 Last updated: 2015-06-30Bibliographically approved

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Welch, KenEngqvist, Håkan
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