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The effect of epistasis on sexually antagonistic genetic variation
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
2014 (English)In: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 281, no 1787, 20140489- p.Article in journal (Refereed) Published
Abstract [en]

There is increasing evidence of segregating sexually antagonistic (SA) genetic variation for fitness in laboratory and wild populations, yet the conditions for the maintenance of such variation can be restrictive. Epistatic interactions between genes can contribute to the maintenance of genetic variance in fitness and we suggest that epistasis between SA genes should be pervasive. Here, we explore its effect on SA genetic variation in fitness using a two locus model with negative epistasis. Our results demonstrate that epistasis often increases the parameter space showing polymorphism for SA loci. This is because selection in one locus is affected by allele frequencies at the other, which can act to balance net selection in males and females. Increased linkage between SA loci had more marginal effects. We also show that under some conditions, large portions of the parameter space evolve to a state where male benefit alleles are fixed at one locus and female benefit alleles at the other. This novel effect of epistasis on SA loci, which we term the 'equity effect', may have important effects on population differentiation and may contribute to speciation. More generally, these results support the suggestion that epistasis contributes to population divergence.

Place, publisher, year, edition, pages
2014. Vol. 281, no 1787, 20140489- p.
Keyword [en]
mutation-order speciation, recombination, gene interaction, sexual dimorphism, sexual conflict, simuPOP
National Category
Evolutionary Biology
URN: urn:nbn:se:uu:diva-229424DOI: 10.1098/rspb.2014.0489ISI: 000338335800013OAI: oai:DiVA.org:uu-229424DiVA: diva2:737086
Available from: 2014-08-11 Created: 2014-08-07 Last updated: 2014-08-11Bibliographically approved

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Arnqvist, Göran
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Animal ecology
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