uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hopsital.
Show others and affiliations
2011 (English)In: Journal of Clinical Investigation, ISSN 0021-9738, E-ISSN 1558-8238, Vol. 121, no 6, 2278-2289 p.Article in journal (Refereed) Published
Abstract [en]

Angiopoietin-1/Tek signaling is a critical regulator of blood vessel development, with conventional knockout of angiopoietin-1 or Tek in mice being embryonically lethal due to vascular defects. In addition, angiopoietin-1 is thought to be required for the stability of mature vessels. Using a Cre-Lox conditional gene targeting approach, we have studied the role of angiopoietin-1 in embryonic and adult vasculature. We report here that angiopoietin-1 is critical for regulating both the number and diameter of developing vessels but is not required for pericyte recruitment. Cardiac-specific knockout of angiopoietin-1 reproduced the phenotype of the conventional knockout, demonstrating that the early vascular abnormalities arise from flow-dependent defects. Strikingly, deletion in the entire embryo after day E13.5 produced no immediate vascular phenotype. However, when combined with injury or microvascular stress, angiopoietin-1 deficiency resulted in profound organ damage, accelerated angiogenesis, and fibrosis. These findings redefine our understanding of the biological roles of angiopoietin-1: it is dispensable in quiescent vessels but has a powerful ability to modulate the vascular response after injury.

Place, publisher, year, edition, pages
2011. Vol. 121, no 6, 2278-2289 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-230110DOI: 10.1172/JCI46322PubMedID: 21606590OAI: oai:DiVA.org:uu-230110DiVA: diva2:738817
Available from: 2014-08-19 Created: 2014-08-19 Last updated: 2014-09-16Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Jeansson, Marie
In the same journal
Journal of Clinical Investigation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 224 hits
ReferencesLink to record
Permanent link

Direct link