New insights into the pathogenesis of cellular crescents
2011 (English)In: Current opinion in nephrology and hypertension, ISSN 1062-4821, E-ISSN 1535-3842, Current opinion in, Vol. 20, no 3, 258-262 p.Article in journal (Refereed) Published
PURPOSE OF REVIEW: This review discusses the recent evidence that intrinsic glomerular cells including podocytes, parietal epithelial cells and progenitor cells within Bowman's capsule contribute to cellular crescents.
RECENT FINDINGS: Using a variety of newer molecular markers and lineage tracing experiments, investigators have clearly demonstrated that glomerular cells play a key role in the development and progression of cellular crescents in experimental and human disease.
SUMMARY: Crescentic glomerulonephritis is associated with significant morbidity and mortality. Current therapies target the immune system. The recent finding that nonimmune cells also play a role in crescent formation highlights the need to identify alternate and complimentary therapeutic strategies.
Place, publisher, year, edition, pages
2011. Vol. 20, no 3, 258-262 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-230111DOI: 10.1097/MNH.0b013e32834583ecPubMedID: 21455064OAI: oai:DiVA.org:uu-230111DiVA: diva2:738818