Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism
2014 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 134, no 2, 426-432 p.Article in journal (Refereed) Published
We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n=2753) from Sweden.
MATERIALS AND METHODS:
39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression.
Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n=7181).
It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.
Place, publisher, year, edition, pages
2014. Vol. 134, no 2, 426-432 p.
Clinical Medicine Cardiac and Cardiovascular Systems Hematology
IdentifiersURN: urn:nbn:se:uu:diva-230554DOI: 10.1016/j.thromres.2014.03.054ISI: 000341309200036PubMedID: 24745723OAI: oai:DiVA.org:uu-230554DiVA: diva2:740964