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Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism
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2014 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 134, no 2, 426-432 p.Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION:

We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n=2753) from Sweden.

MATERIALS AND METHODS:

39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression.

RESULTS:

Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n=7181).

CONCLUSIONS:

It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.

Place, publisher, year, edition, pages
2014. Vol. 134, no 2, 426-432 p.
National Category
Clinical Medicine Cardiac and Cardiovascular Systems Hematology
Identifiers
URN: urn:nbn:se:uu:diva-230554DOI: 10.1016/j.thromres.2014.03.054ISI: 000341309200036PubMedID: 24745723OAI: oai:DiVA.org:uu-230554DiVA: diva2:740964
Available from: 2014-08-26 Created: 2014-08-26 Last updated: 2017-12-05Bibliographically approved

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Syvänen, Ann-Christine

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