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New trends in rectal cancer treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Colorectal Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Colorectal Surgery.
2014 (English)In: The Open Colorectal Cancer Journal, ISSN 1876-8202, E-ISSN 1876-8202, Vol. 3, no 2, 215-222 p.Article in journal (Refereed) Published
Abstract [en]

The treatment philosophy for rectal cancer has changed a lot during the last three decades. In the 1970s it was more or less a pure surgical business and rectal cancer was considered radiation resistant. Owing to the unacceptable high local recurrence rates, surgery was changed (the total mesorectal excision technique) during the 1980s and treatment was, in many countries, concentrated to lager units. Moreover, the addition of adjuvant radiotherapy was tested during the same period in several randomized trials and demonstrated that the local recurrence rate could be reduced by 50%, provided the radiation dose was high enough. Since then, treatment has changed very rapidly with several interesting approaches, such as timing and type of radiotherapy, the place of chemotherapy, surgery with modern technique including laparoscopy; natural orifice transendoscopic surgery or robotics; and the whole idea of ‘wait-and-watch’ program. All of these new aspects are covered and discussed in the view of the standard-of-care in 2014.

Place, publisher, year, edition, pages
2014. Vol. 3, no 2, 215-222 p.
National Category
Surgery
Identifiers
URN: urn:nbn:se:uu:diva-230660DOI: 10.2217/crc.14.7OAI: oai:DiVA.org:uu-230660DiVA: diva2:741260
Available from: 2014-08-27 Created: 2014-08-27 Last updated: 2017-12-05Bibliographically approved

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Påhlman, LarsFolkesson, Joakim

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