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Rapid Increase of Interleukin-10 Plasma Levels After Combined Auxiliary Liver-Kidney Transplantation in Presensitized Patients
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2014 (English)In: Transplantation, ISSN 0041-1337, E-ISSN 1534-6080, Vol. 98, no 2, 208-215 p.Article in journal (Refereed) Published
Abstract [en]

Background. After transplantation, donor dendritic cells (DCs) in the grafted organ are activated by an ischemia/reperfusion-induced inflammatory process that induces their migration to the recipient's secondary lymphoid tissues. The subsequent interaction between migrated and mature donor DCs, recipient T cells, and natural killer (NK) cells is proposed to be crucial in directing host immune reactions toward allograft rejection. A liver transplant is less prone to induce rejection compared with most other solid organ transplants, and simultaneous transplantation of liver and kidney is known to improve the clinical outcome of kidney transplantation. Methods and Results. Here we show that liver as well as combined auxiliary liver-kidney transplantation in patients induces a rapid increase in plasma interleukin-10 (IL-10) to levels that are significantly higher than those seen after standard kidney transplantation. Addition of IL-10 during in vitro maturation of human monocyte-derived DCs with ischemia/reperfusion-associated factors was found to affect phenotypic DC maturation significantly. Addition of IL-10 inhibited DC production of the NK cell- and T cell-recruiting chemokines CXCL9, CXCL10 and CXCL11. Conclusion. Our findings indicate that liver transplantation induces a substantial systemic release of IL-10, which may inhibit T cell- and NK cell- mediated rejection processes toward the transplanted liver and concurrently transplanted kidney.

Place, publisher, year, edition, pages
2014. Vol. 98, no 2, 208-215 p.
Keyword [en]
Dendritic cells, Allograft rejection, Tolerance, Chemokine, Interleukin-10
National Category
Surgery Immunology in the medical area
URN: urn:nbn:se:uu:diva-230083DOI: 10.1097/TP.0000000000000038ISI: 000339262000018PubMedID: 24598935OAI: oai:DiVA.org:uu-230083DiVA: diva2:743141
Available from: 2014-09-03 Created: 2014-08-19 Last updated: 2014-09-03Bibliographically approved

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Karlsson-Parra, Alex
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