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Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
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2014 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 57, no 8, 1561-1568 p.Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved. Methods An observational survey with prospective follow-up including 911 non-diabetic Swedish men aged 70-71 years was carried out. The gold standard euglycaemic-hyperinsulinaemic clamp technique and the OGTT were used to determine insulin sensitivity and beta cell function, respectively. Diabetes incidence was assessed during 18 years of follow-up. Renal function was estimated from serum cystatin C concentrations. Dietary acid load was calculated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) algorithms from 7 day food records. Adequate dietary reporters were identified by Goldberg cut-offs. Results PRAL and NEAP were not associated with insulin sensitivity or beta cell function. Underlying kidney function or consideration of dietary adequate reporters did not modify these null findings. During follow-up, 115 new cases of diabetes were validated. Neither PRAL nor NEAP was associated with diabetes incidence. Conclusios/interpretation Our results do not support the hypothesis that dietary acid load influences insulin sensitivity, beta cell function or diabetes risk. Interventional studies modifying acid-base dietary intake are needed to further elucidate a possible role of acid load in the development of type 2 diabetes.

Place, publisher, year, edition, pages
2014. Vol. 57, no 8, 1561-1568 p.
Keyword [en]
Diabetes incidence, Dietary acid load, Insulin resistance, Insulin sensitivity, Kidney function
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:uu:diva-230066DOI: 10.1007/s00125-014-3275-zISI: 000338997500006PubMedID: 24875749OAI: oai:DiVA.org:uu-230066DiVA: diva2:743259
Available from: 2014-09-03 Created: 2014-08-19 Last updated: 2014-09-03Bibliographically approved

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Riserus, UlfCederholm, TommyÄrnlöv, JohanSjögren, Per
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