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Are Increased Levels of Systemic Oxidative Stress and Inflammation Associated with Age-Related Cataract?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
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2014 (English)In: Antioxidants and Redox Signaling, ISSN 1523-0864, E-ISSN 1557-7716, Vol. 21, no 5, 700-704 p.Article in journal (Refereed) Published
Abstract [en]

Oxidative stress and inflammation may be involved in the etiology of age-related cataract. This study is the first to investigate the association between urinary levels of 8-iso-prostaglandin F-2 alpha (PGF(2 alpha); as a biomarker for systemic oxidative stress in vivo) and 15-keto-dihydro-PGF(2 alpha) (as a biomarker for systemic inflammation in vivo) and risk of age-related cataract. We observed in a nested case-control study, including 258 women with incident cataract diagnosis and/or cataract extraction and 258 women without cataract, matched on age and date of urine sample collection that, women with higher levels of urinary 8-iso-PGF(2 alpha) as compared with lower levels had an increased risk of age-related cataract. There was no difference in 15-keto-dihydro-PGF(2 alpha) levels between cases and controls. Our observations lead to the hypothesis that higher systemic oxidative stress increases the risk of developing age-related cataract.

Place, publisher, year, edition, pages
2014. Vol. 21, no 5, 700-704 p.
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Cell and Molecular Biology
URN: urn:nbn:se:uu:diva-231105DOI: 10.1089/ars.2014.5853ISI: 000339660000003PubMedID: 24527727OAI: oai:DiVA.org:uu-231105DiVA: diva2:744183
Available from: 2014-09-07 Created: 2014-09-04 Last updated: 2014-09-07Bibliographically approved

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Michaëlsson, KarlBasu, Samar
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OrthopaedicsUCR-Uppsala Clinical Research CenterOxidative Stress and Inflammation
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Antioxidants and Redox Signaling
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