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Are Increased Levels of Systemic Oxidative Stress and Inflammation Associated with Age-Related Cataract?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
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2014 (English)In: Antioxidants and Redox Signaling, ISSN 1523-0864, E-ISSN 1557-7716, Vol. 21, no 5, 700-704 p.Article in journal (Refereed) Published
Abstract [en]

Oxidative stress and inflammation may be involved in the etiology of age-related cataract. This study is the first to investigate the association between urinary levels of 8-iso-prostaglandin F-2 alpha (PGF(2 alpha); as a biomarker for systemic oxidative stress in vivo) and 15-keto-dihydro-PGF(2 alpha) (as a biomarker for systemic inflammation in vivo) and risk of age-related cataract. We observed in a nested case-control study, including 258 women with incident cataract diagnosis and/or cataract extraction and 258 women without cataract, matched on age and date of urine sample collection that, women with higher levels of urinary 8-iso-PGF(2 alpha) as compared with lower levels had an increased risk of age-related cataract. There was no difference in 15-keto-dihydro-PGF(2 alpha) levels between cases and controls. Our observations lead to the hypothesis that higher systemic oxidative stress increases the risk of developing age-related cataract.

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2014. Vol. 21, no 5, 700-704 p.
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Cell and Molecular Biology
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URN: urn:nbn:se:uu:diva-231105DOI: 10.1089/ars.2014.5853ISI: 000339660000003PubMedID: 24527727OAI: oai:DiVA.org:uu-231105DiVA: diva2:744183
Available from: 2014-09-07 Created: 2014-09-04 Last updated: 2017-12-05

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Michaëlsson, KarlBasu, Samar

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