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Analysis of l-[methyl-11C]methionine and metabolites in human plasma by an automated solid-phase extraction and a high-performance liquid chromatographic procedure
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry. (Uppsala University PET Centre)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry. (Uppsala University PET Centre)
(Uppsala University PET Centre)
(Uppsala University PET Centre)
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1996 (English)In: Journal of Chromatography B: Biomedical Sciences and Applications, ISSN 1387-2273, E-ISSN 1878-5603, Vol. 679, no 1-2, 13-19 p.Article in journal (Refereed) Published
Abstract [en]

A fully automated method for separation of l-[methyl-11C]Methionine from metabolites in patient plasma was developed. l-[methyl-11C]Methionine was isolated from plasma by solid-phase extraction (SPE). The radioactivity retained on the SPE column was eluted and injected onto the HPLC system for separation of in vivo formed l-[methyl-11C]methionine radiolabeled metabolites. The yield through the isolation procedure and HPLC analysis was greater than 95% with a precision better than 5% (R.S.D.). The calculated rate of l-[methyl-11C]methionine transport into tumor tissue was markedly different with and without compensation for radiolabeled metabolises in patient plasma.

Place, publisher, year, edition, pages
1996. Vol. 679, no 1-2, 13-19 p.
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Clinical Medicine
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URN: urn:nbn:se:uu:diva-231359DOI: 10.1016/0378-4347(96)00011-4PubMedID: 8998552OAI: oai:DiVA.org:uu-231359DiVA: diva2:744346
Available from: 2014-09-08 Created: 2014-09-08 Last updated: 2017-12-05Bibliographically approved

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Tyrefors, NiklasSundin, AndersLångström, Bengt

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