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Lack of distant migration after injection of a 125iodine labeled dextranomer based implant into the rabbit bladder
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Paediatric Surgery.
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1997 (English)In: Journal of Urology, ISSN 0022-5347, E-ISSN 1527-3792, Vol. 158, no 5, 1937-1941 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE:

In recent years endoscopic treatment of stress incontinence and vesicoureteral reflux has been introduced. Reports of possible particle migration of the injected material to distant organs in humans and experimental animals have led to a search for biological nonmigration products. An implant found to have a good clinical effect in these conditions is dextranomer in hyaluronan. We performed this study in rabbits to investigate the possible migration of dextranomer particles.

MATERIALS AND METHODS:

125Iodine labeled dextranomer particles were injected into the submucosal space of rabbit bladders, and samples of blood and various tissues were examined for radioactivity at scheduled intervals during a 28-day period. Furthermore, whole body autoradiography was performed 1 day, and 1 and 4 weeks after injection.

RESULTS:

Radioactivity was found in blood samples and in all tissues but it remained at the background activity level except in the thyroid, where uptake representing free 125iodine was detected. In the bladder 41 and 45% of the injected dose remained within the bladder wall 1 day and 4 weeks, respectively, after injection. The remainder of the dose probably disappeared from the bladder wall by leakage into the urine shortly after deposition, as indicated by the finding of 10-fold higher urine radioactivity levels at day 1 than at day 28 after injection.

CONCLUSIONS:

No distant migration of dextranomer particles occurs after submucosal injection of such an implant in the rabbit bladder wall.

Place, publisher, year, edition, pages
1997. Vol. 158, no 5, 1937-1941 p.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:uu:diva-231366DOI: 10.1016/S0022-5347(01)64185-5PubMedID: 9334643OAI: oai:DiVA.org:uu-231366DiVA: diva2:744351
Available from: 2014-09-08 Created: 2014-09-08 Last updated: 2017-12-05Bibliographically approved

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Sundin, AndersLäckgren, GöranStenberg, Arne

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