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Synthesis of l-2,4-Diamino[4-11C]butyric acid and its use in some In vitro and In vivo tumour models
(Uppsala University Pet-Centre, Uppsala, Sweden)
(Uppsala University Pet-Centre, Uppsala, Sweden)
(Uppsala University Pet-Centre, Uppsala, Sweden)
(Uppsala University Pet-Centre, Uppsala, Sweden)
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1997 (English)In: Nuclear Medicine and Biology, ISSN 0969-8051, E-ISSN 1872-9614, Vol. 24, no 6, 595-601 p.Article in journal (Refereed) Published
Abstract [en]

l-2,4-Diamino[4-11C]butyric acid (DAB) was synthesized by an enzyme catalysed carrier added (0.1 μmol KCN) reaction of hydrogen [11C]cyanide with O-acetyl-l-serine followed by reduction. l-[11C]DAB was obtained with a radiochemical purity higher than 96% and with a decay corrected radiochemical yield of 30–40% within a 32 min reaction time. The enantiomeric excess was 98%. The uptake of l-[11C]DAB was investigated in multicellular aggregates of six different cell lines and animal tumour models. l-[11C]DAB is potentially useful for the assessment of pharmacokinetics of l-DAB in vivo for part of its evaluation as an antitumoural agent, although its use for diagnostic purposes seems limited.

Place, publisher, year, edition, pages
1997. Vol. 24, no 6, 595-601 p.
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-231367DOI: 10.1016/S0969-8051(97)00032-2PubMedID: 9316090OAI: oai:DiVA.org:uu-231367DiVA: diva2:744355
Available from: 2014-09-08 Created: 2014-09-08 Last updated: 2017-12-05Bibliographically approved

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Antoni, GunnarSundin, AndersLångström, Bengt

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