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68Ga-DOTA-TOC-PET/CT detects heart metastases from ileal neuroendocrine tumors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. Department of Radiology, Karolinska University Hospital, Stockholm, Sweden .
2014 (English)In: Endocrine, ISSN 1559-0100, Vol. 47, no 1, 169-176 p.Article in journal (Refereed) Published
Abstract [en]

Metastases from ileal neuroendocrine tumors (NETs) to the myocardium are rare and generally seen in patients with widespread metastatic NET disease. The objectives of this investigation were to describe the frequency of intracardiac metastases in ileal NET patients examined by 68Ga-DOTA-TOC-PET/CT and to describe the cases in detail. All 68Ga-DOTA-TOC-PET/CT examinations performed at the Karolinska University Hospital since 2010 until April 2012 were reviewed. In all, 128 out of 337 examinations were in patients with ileal NETs. Four patients had seven myocardiac metastases, yielding a frequency of 4.3 % in patients with ileal NETs. One patient had cardiac surgery while three were treated with somatostatin analogs. The cardiac metastases did not affect the patients’ activity of daily life. 68Ga-DOTA-TOC-PET/CT is an established imaging modality in identifying cardiac metastases in ileal NETs. Prospective studies are needed to confirm the true clinical value of 68Ga-DOTA-TOC-PET/CT in detecting cardiac metastases in both ileal and non-ileal NETs.

Place, publisher, year, edition, pages
2014. Vol. 47, no 1, 169-176 p.
National Category
Clinical Medicine
URN: urn:nbn:se:uu:diva-231420DOI: 10.1007/s12020-013-0108-7PubMedID: 24272595OAI: oai:DiVA.org:uu-231420DiVA: diva2:744549
Available from: 2014-09-08 Created: 2014-09-08 Last updated: 2015-03-25Bibliographically approved

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