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Serum levels of monobenzylphthalate (MBzP) is related to carotid atherosclerosis in the elderly
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.ORCID iD: 0000-0002-8949-3555
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
2014 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 133, 348-352 p.Article in journal (Refereed) Published
Abstract [en]

Background and objective: Background exposure to environmental contaminants has recently emerged as a new risk factor for cardiovascular disease in general and to atheroclerosis in particular. This cross-sectional study was performed to evaluate if serum concentrations of the phthalate metabolite monobenzylphthalate (MBzP) are related to atheroclerosis in the carotid arteries. Methods: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1003 subjects all aged 70) the prevalence of overt plaques and echogenicity (gray-scale median, GSM) of carotid artery plaques were recorded by ultrasound in both of the carotid arteries. The intima-media thickness (IMT) and echogenicity (IM-GSM) of the intima-media complex were also measured. The phthalate metabolite MBzP was analyzed in serum by a liquid chromatograph/tandem mass spectrometer. Results: The circulating level of the phthalate MBzP was related to intima-media thickness (IMT) when adjusting for gender, blood pressure, body mass index (BMI), waist circumference, HDL- and LDL-cholesterol, serum triglycerides, blood glucose and smoking (p=0.034). High levels of MBzP were also strongly associated with an echogenic IM-GSM and plaque GSM (p=0.0001 for both outcomes after adjustment) but not to plaque prevalence (p=0.42). Conclusion: The phthalate metabolite MBzP was strongly related to the echogenicity of intima-media and plaques and also to IMT, independently of traditional CV risk factors. This suggests a role for the phthalate MBzP in the development of atherosclerosis.

Place, publisher, year, edition, pages
2014. Vol. 133, 348-352 p.
Keyword [en]
Phthalate, Endocrine disruptor, Atherosclerosis, Carotids, Intima media thickness
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:uu:diva-231234DOI: 10.1016/j.envres.2014.06.009ISI: 000339705900045OAI: oai:DiVA.org:uu-231234DiVA: diva2:744625
Available from: 2014-09-08 Created: 2014-09-05 Last updated: 2017-12-05Bibliographically approved

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Wiberg, BerniceLind, MonicaLind, Lars

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