Serum levels of monobenzylphthalate (MBzP) is related to carotid atherosclerosis in the elderly
2014 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 133, 348-352 p.Article in journal (Refereed) Published
Background and objective: Background exposure to environmental contaminants has recently emerged as a new risk factor for cardiovascular disease in general and to atheroclerosis in particular. This cross-sectional study was performed to evaluate if serum concentrations of the phthalate metabolite monobenzylphthalate (MBzP) are related to atheroclerosis in the carotid arteries. Methods: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1003 subjects all aged 70) the prevalence of overt plaques and echogenicity (gray-scale median, GSM) of carotid artery plaques were recorded by ultrasound in both of the carotid arteries. The intima-media thickness (IMT) and echogenicity (IM-GSM) of the intima-media complex were also measured. The phthalate metabolite MBzP was analyzed in serum by a liquid chromatograph/tandem mass spectrometer. Results: The circulating level of the phthalate MBzP was related to intima-media thickness (IMT) when adjusting for gender, blood pressure, body mass index (BMI), waist circumference, HDL- and LDL-cholesterol, serum triglycerides, blood glucose and smoking (p=0.034). High levels of MBzP were also strongly associated with an echogenic IM-GSM and plaque GSM (p=0.0001 for both outcomes after adjustment) but not to plaque prevalence (p=0.42). Conclusion: The phthalate metabolite MBzP was strongly related to the echogenicity of intima-media and plaques and also to IMT, independently of traditional CV risk factors. This suggests a role for the phthalate MBzP in the development of atherosclerosis.
Place, publisher, year, edition, pages
2014. Vol. 133, 348-352 p.
Phthalate, Endocrine disruptor, Atherosclerosis, Carotids, Intima media thickness
Environmental Health and Occupational Health
IdentifiersURN: urn:nbn:se:uu:diva-231234DOI: 10.1016/j.envres.2014.06.009ISI: 000339705900045OAI: oai:DiVA.org:uu-231234DiVA: diva2:744625