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Anti-inflammatory effect by exclusive enteral nutrition (EEN) in a patient with juvenile idiopathic arthritis (JIA): brief report
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
2014 (English)In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 33, no 8, 1173-1175 p.Article in journal (Refereed) Published
Abstract [en]

There is extensive evidence for influence of gut microbiota on health. Exclusive enteral nutrition (EEN) possibly changes gut microbiota, but the exact pathophysiological role is unknown. EEN has been shown to have an anti-inflammatory effect in children with Mb Crohn, an inflammatory bowel disease. The intestinal tract is very scarcely studied in children with juvenile idiopathic arthritis (JIA), but data points to an immunologically important role. The aim of this study was to explore if EEN had any anti-inflammatory effect in children with JIA. The first patient enrolled in the study was followed for 1 year. She had onset of severe polyarticular disease at 3.2 years of age, negative in RF, anti-CCP, ANA, and HLA-B27. She was included in the study at 7.4 years of age. Exclusive enteral nutrition was given in two periods of almost 7 weeks each, several months apart, during the year of the study. Clinical and laboratory status were assessed before, during, and after treatment periods. In this patient, EEN had remarkable anti-inflammatory effect that was sustained for months after each of two separate treatment periods. Exclusive enteral nutrition is a possible anti-inflammatory treatment in patients with JIA, but to what extent EEN is effective in other children with JIA needs to be explored, as well as the possible pathophysiological role of EEN in those children.

Place, publisher, year, edition, pages
2014. Vol. 33, no 8, 1173-1175 p.
Keyword [en]
Arthritis, Child, Exclusive enteral nutrition, Joints, Juvenile idiopathic arthritis
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:uu:diva-231232DOI: 10.1007/s10067-014-2672-5ISI: 000339731800023PubMedID: 24852669OAI: oai:DiVA.org:uu-231232DiVA: diva2:744627
Available from: 2014-09-08 Created: 2014-09-05 Last updated: 2014-09-08Bibliographically approved

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