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Local immunotherapy based on agonistic CD40 antibodies effectively inhibits experimental bladder cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
2014 (English)In: Oncoimmunology, ISSN 2162-4011, E-ISSN 2162-402X, Vol. 3, no 2, e27400Article in journal, Editorial material (Other academic) Published
Abstract [en]

Local immunotherapy resurfaces in the field of cancer as a potential way to cure localized and metastatic disease with limited toxic effects. We have recently demonstrated that local administration of agonistic CD40 antibodies can cure localized as well as disseminated bladder neoplasms. This approach reduces the circulating concentrations of antibodies that would result from systemic delivery, hence resulting in limited toxicity.

Place, publisher, year, edition, pages
2014. Vol. 3, no 2, e27400
Keyword [en]
antibody, bladder cancer, CD40, local immunotherapy
National Category
Immunology in the medical area Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-231498DOI: 10.4161/onci.27400ISI: 000339952700020OAI: oai:DiVA.org:uu-231498DiVA: diva2:744628
Available from: 2014-09-08 Created: 2014-09-08 Last updated: 2017-12-05Bibliographically approved

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Tötterman, Thomas H.Mangsbo, Sara M.

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