uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Altered chemokine production and accumulation of regulatory T cells in intestinal adenomas of APC(Min/+) mice
Show others and affiliations
2014 (English)In: Cancer Immunology and Immunotherapy, ISSN 0340-7004, E-ISSN 1432-0851, Vol. 63, no 8, 807-819 p.Article in journal (Refereed) Published
Abstract [en]

Tumor progression in the colon moves from aberrant crypt foci to adenomatous polyps to invasive carcinomas. The composition of the tumor-infiltrating leukocyte population affects the ability of the immune system to fight the tumor. T cell infiltration into colorectal adenocarcinomas, particularly T helper 1 (Th1) type T cells as well as increased regulatory T cell (Treg) frequencies, is correlated with improved prognosis. However, whether Th1 cells and Tregs are already present at the adenoma stage is not known. In this study, the APC(Min/+) mouse model of intestinal adenomatous polyposis was used to investigate tumor-associated lymphocyte subsets and the mechanisms of their accumulation into gastrointestinal adenomas. Compared to unaffected tissue, adenomas accumulated CD4(+)FoxP3(+) putative Treg in parallel with lower frequencies of conventional T cells and B cells. The accumulation of Treg was also observed in human adenomatous polyps. Despite high Treg numbers, the function of conventional T cells present in the APC(Min/+) adenomas was not different from those in the unaffected tissue. Adenomas displayed an altered chemokine balance, with higher CCL17 and lower CXCL11 and CCL25 expression than in the unaffected tissue. In parallel, CXCR3(+) Tregs were largely absent from adenomas. The data indicate that already in early stages of tumor development, the balance of lymphocyte-recruiting chemokines is altered possibly contributing to the observed shift toward higher frequencies of Treg.

Place, publisher, year, edition, pages
2014. Vol. 63, no 8, 807-819 p.
Keyword [en]
Regulatory T cells, Tumor-infiltrating lymphocytes, Colorectal cancer, APC(Min/+), Anti-tumor immunity, Chemokines
National Category
Cancer and Oncology Immunology in the medical area
URN: urn:nbn:se:uu:diva-231230DOI: 10.1007/s00262-014-1555-6ISI: 000339873500005OAI: oai:DiVA.org:uu-231230DiVA: diva2:744679
Available from: 2014-09-08 Created: 2014-09-05 Last updated: 2014-09-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Department of Immunology, Genetics and Pathology
In the same journal
Cancer Immunology and Immunotherapy
Cancer and OncologyImmunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 238 hits
ReferencesLink to record
Permanent link

Direct link