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Viruses and oral cancer. Is there a link?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery.
2014 (English)In: Microbes and infection, ISSN 1286-4579, E-ISSN 1769-714X, Vol. 16, no 5, 371-378 p.Article, review/survey (Refereed) Published
Abstract [en]

Oral squamous cell carcinoma (OSCC) is the most common malignant tumour of the oral cavity. The aetiology of epithelial cancer of the head and neck is considered to be a multifactorial, sequential process. DNA viruses are found in many different cancers and are also capable of transforming cells to a malignant phenotype. Human Papilloma Virus (HPV) has been proposed as risk factors in OSCC development and HPV type 16 is the most important subtype. Other oncogenic virus species i.e., Epstein-Barr Virus and Herpes Simplex Virus Type 1 have been proposed to be involved in oral carcinogenesis. However, no convincing evidence exist that they are an established risk factor in OSCC. Therefore more studies are needed in order to clarify the different aspects of virus involvement. Here, we review the existing literature on viral involvement in oral cancer.

Place, publisher, year, edition, pages
2014. Vol. 16, no 5, 371-378 p.
National Category
Surgery Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-231576DOI: 10.1016/j.micinf.2014.02.009ISI: 000347866500002PubMedID: 24613199OAI: oai:DiVA.org:uu-231576DiVA: diva2:744951
Available from: 2014-09-09 Created: 2014-09-09 Last updated: 2017-12-05Bibliographically approved

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Sand, LarsJalouli, Jamshid

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