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Pulse-modulated feedback in mathematical modeling and estimation of endocrine systems
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control.
2014 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

The research field of systems biology has gained a lot of interest during the last decades. Systems biology can be seen as the systematic study of complex interactions in biological systems, mainly by methods from dynamical systems theory. This thesis mainly deals with the testosterone (Te) regulation in the human male, but techniques developed here might be useful for studying other parts of the endocrine system too. The contribution of the thesis can be divided into two parts: one covering mathematical models of Te regulation and another suggesting and validating identification techniques for those models. Regarding modeling, existing models of testosterone regulation have been extended with time delays and nonlinear dynamics, with the purpose of achieving better fit to clinical data. The identification part treats the estimation of unknown model parameters, and estimation of signals that cannot be measured in a noninvasive way.

Place, publisher, year, edition, pages
Uppsala University, 2014.
Series
Information technology licentiate theses: Licentiate theses from the Department of Information Technology, ISSN 1404-5117 ; 2014-006
National Category
Control Engineering
Research subject
Electrical Engineering with specialization in Automatic Control
Identifiers
URN: urn:nbn:se:uu:diva-231908OAI: oai:DiVA.org:uu-231908DiVA: diva2:745656
Presentation
2014-09-09, Room 2003, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 10:15 (English)
Supervisors
Available from: 2014-09-09 Created: 2014-09-10 Last updated: 2017-08-31Bibliographically approved
List of papers
1. Estimation of input impulses by means of continuous finite memory observers
Open this publication in new window or tab >>Estimation of input impulses by means of continuous finite memory observers
2012 (English)In: Proc. American Control Conference: ACC 2012, American Automatic Control Council , 2012, 6769-6774 p.Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
American Automatic Control Council, 2012
National Category
Control Engineering
Identifiers
urn:nbn:se:uu:diva-231905 (URN)10.1109/ACC.2012.6315605 (DOI)978-1-4577-1095-7 (ISBN)
Conference
ACC 2012, June 27-29, Montréal, Canada
Available from: 2012-06-29 Created: 2014-09-10 Last updated: 2014-09-10Bibliographically approved
2. State estimation in linear time-invariant systems with unknown impulsive inputs
Open this publication in new window or tab >>State estimation in linear time-invariant systems with unknown impulsive inputs
2013 (English)In: Proc. 12th European Control Conference, IEEE , 2013, 1675-1680 p.Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
IEEE, 2013
National Category
Control Engineering
Identifiers
urn:nbn:se:uu:diva-224183 (URN)000332509702012 ()978-3-033-03962-9 (ISBN)
Conference
ECC 2013, July 17-19, Zürich, Switzerland
Available from: 2013-07-19 Created: 2014-05-05 Last updated: 2014-09-10Bibliographically approved
3. Periodical solutions in a pulse-modulated model of endocrine regulation with time-delay
Open this publication in new window or tab >>Periodical solutions in a pulse-modulated model of endocrine regulation with time-delay
2014 (English)In: IEEE Transactions on Automatic Control, ISSN 0018-9286, E-ISSN 1558-2523, Vol. 59, no 3, 728-733 p.Article in journal (Refereed) Published
National Category
Control Engineering
Identifiers
urn:nbn:se:uu:diva-222396 (URN)10.1109/TAC.2013.2273284 (DOI)000332037800013 ()
Available from: 2014-02-19 Created: 2014-04-10 Last updated: 2017-12-05Bibliographically approved
4. Modeling of testosterone regulation by pulse-modulated feedback: An experimental data study
Open this publication in new window or tab >>Modeling of testosterone regulation by pulse-modulated feedback: An experimental data study
2013 (English)In: International Symposium on Computational Models for Life Sciences: CMLS 2013, Melville, NY: American Institute of Physics (AIP), 2013, 333-342 p.Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Melville, NY: American Institute of Physics (AIP), 2013
Series
AIP Conference Proceedings, 1559
National Category
Control Engineering
Identifiers
urn:nbn:se:uu:diva-221216 (URN)10.1063/1.4825027 (DOI)000331467600039 ()978-0-7354-1187-6 (ISBN)
Conference
CMLS 2013, November 27-29, Sydney, Australia
Available from: 2013-10-09 Created: 2014-03-26 Last updated: 2014-09-10Bibliographically approved

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Mattsson, Per

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