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HAS2 and CD44 in Breast Tumorigenesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab.
2014 (English)In: Hyaluronan Signaling and Turnover / [ed] Simpson, MA and Heldin, P, Elsevier, 2014, Vol. 123, 211-229 p.Chapter in book (Refereed)
Abstract [en]

Metastatic spread of breast cancer cells, facilitated by the epithelial-mesenchymal transition (EMT) process, is responsible for the majority of breast cancer mortality. Increased levels of hyaluronan due to deregulation of hyaluronan-synthesizing enzymes, like HAS2, and expression of CD44, the key receptor for hyaluronan, are correlated to poor outcome of patients with basal-like breast cancer. TGFβ induces HAS2 and CD44, both of which are required in the course of efficient TGFβ-induced EMT processes by mammary epithelial cells. Elucidation of the molecular mechanisms underlying tumor-stroma interactions in breast cancer including the regulation of HAS2 and CD44 expression may contribute to the development of better strategies to treat breast cancer patients.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 123, 211-229 p.
Series
Advances in Cancer Research, ISSN 0065-230X ; 123
Keyword [en]
Epithelial-Mesenchymal Transition, Cancer Cell-Lines, Hyaluronan Synthase 2, Growth Factor-Bb, Gene-Expression, Tgf-Beta, Stem-Cells, Tumor Microenvironment, Adhesion Molecules, Mesothelial Cells
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:uu:diva-231936DOI: 10.1016/B978-0-12-800092-2.00008-3ISI: 000340575400016PubMedID: 25081531ISBN: 978-0-12-800092-2 (print)OAI: oai:DiVA.org:uu-231936DiVA: diva2:746005
Available from: 2014-09-11 Created: 2014-09-11 Last updated: 2014-10-01Bibliographically approved

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Heldin, ParaskeviBasu, KaustuvKozlova, Inna

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Ludwig Institute for Cancer ResearchScience for Life Laboratory, SciLifeLabDepartment of Medical Biochemistry and Microbiology
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