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Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma
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2014 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 134, no 9, 959-963 p.Article in journal (Refereed) Published
Abstract [en]

Conclusions: Increased expression of Dicer may be a prognostic biomarker for patients with laryngeal squamous cell carcinoma (LSCC). Objectives: Recent studies have shown that many microRNAs (miRNAs) play an important role in the development and progression of human cancers. Dicer, one of the most important enzymes of the miRNA machinery, performs the final step of biogenesis of miRNAs. This study aimed to investigate the impact of Dicer expression on patient survival in human LSCC. Methods: We detected the expression of Dicer in larynx tissue specimens from 76 LSCC samples and 26 polyps by immunohistochemistry. The clinicopathological and prognostic significance of Dicer expression was investigated in LSCC. Results: Our data showed that the expression of Dicer was significantly higher in the LSCC than in the polyp tissue specimens. Moreover, the expression level of Dicer was significantly associated with the pTNM stage and tumor lymph node metastasis. Kaplan-Meier survival analyses revealed a strong association between tumor Dicer expression and the survival of the patients with LSCC.

Place, publisher, year, edition, pages
2014. Vol. 134, no 9, 959-963 p.
Keyword [en]
Larynx, cancer, metastasis, biomarker
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URN: urn:nbn:se:uu:diva-231978DOI: 10.3109/00016489.2014.920962ISI: 000340462000011OAI: oai:DiVA.org:uu-231978DiVA: diva2:747065
Available from: 2014-09-15 Created: 2014-09-12 Last updated: 2014-09-15Bibliographically approved

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Anniko, Matti
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Otolaryngology and Head and Neck Surgery
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