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Decay times in turnover statistics of single enzymes
2008 (English)In: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics, ISSN 1539-3755, E-ISSN 1550-2376, Vol. 78, no 1 Pt 1, 010901- p.Article in journal (Refereed) Published
Abstract [en]

The first passage times for enzymatic turnovers in nonequilibrium steady state display a statistical symmetry property related to nonequilibrium fluctuation theorems, which makes it possible to extract the chemical driving force from single molecule trajectories in nonequilibrium steady state. Below, we show that the number of decay constants needed to describe the first passage time distribution of this system is not equal to the number of states in the first passage problem, as one would generally expect. Instead, the structure of the kinetic mechanism makes half of the decay times vanish identically from the turnover time distribution. The terms that cancel out correspond to the eigenvalues of a certain submatrix of the master equation matrix for the first exit time problem. We discuss how these results make modeling and data analysis easier for such systems, and how the turnovers can be measured.

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2008. Vol. 78, no 1 Pt 1, 010901- p.
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URN: urn:nbn:se:uu:diva-232515DOI: 10.1103/PhysRevE.78.010901PubMedID: 18763911OAI: oai:DiVA.org:uu-232515DiVA: diva2:748495
Available from: 2014-09-19 Created: 2014-09-19 Last updated: 2017-12-05Bibliographically approved

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Lindén, Martin

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