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Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
2014 (English)In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 19, no 9, 13161-13176 p.Article, review/survey (Refereed) Published
Abstract [en]

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Globally, tuberculosis is second only to AIDS in mortality and the disease is responsible for over 1.3 million deaths each year. The impractically long treatment schedules (generally 6-9 months) and unpleasant side effects of the current drugs often lead to poor patient compliance, which in turn has resulted in the emergence of multi-, extensively- and totally-drug resistant strains. The development of new classes of anti-tuberculosis drugs and new drug targets is of global importance, since attacking the bacterium using multiple strategies provides the best means to prevent resistance. This review presents an overview of the various strategies and compounds utilized to inhibit glutamine synthetase, a promising target for the development of drugs for TB therapy.

Place, publisher, year, edition, pages
2014. Vol. 19, no 9, 13161-13176 p.
National Category
Organic Chemistry Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-232717DOI: 10.3390/molecules190913161ISI: 000343093100016PubMedID: 25162957OAI: oai:DiVA.org:uu-232717DiVA: diva2:749220
Available from: 2014-09-23 Created: 2014-09-23 Last updated: 2017-12-05Bibliographically approved

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Mowbray, Sherry LOdell, Luke R

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