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Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
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2014 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 345, no 6200, 1074-1079 p.Article in journal (Refereed) Published
Abstract [en]

The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.

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2014. Vol. 345, no 6200, 1074-1079 p.
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URN: urn:nbn:se:uu:diva-232593DOI: 10.1126/science.1253714ISI: 000340870900046OAI: oai:DiVA.org:uu-232593DiVA: diva2:749547

De två sista författarna delar sistaförfattarskapet (Andersson och Lindblad-Toh)

Available from: 2014-09-24 Created: 2014-09-22 Last updated: 2015-02-26Bibliographically approved

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Rubin, Carl-JohanBarrio, Alvaro MartinezPielberg, GerliRafati, NimaYounis, ShadyXiong, AnqiForsberg-Nilsson, KarinLindblad-Toh, KerstinAndersson, Leif
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Department of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLabCancer and Vascular Biology
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